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Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness to minimize the risk of hypoglycemia or hyperglycemia [see Warnings and Precautions (5.2) and Use in Specific Populations (8.6, 8.7)]

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Our results indicate that DDA complexes with GSH-AuNCs and readily induces their complete transfer to chloroform or dichloromethane (typical solvents to prepare PLGA nanoparticles) as well as to other hydrophobic solvents (hexane and toluene) as shown in Fig