The 3D structure of ER -DNA complex contained stable interactions, such as H-bonds (formed between polar donors (e.g., N-H) and acceptors (e.g., O, N), energy range in 1040 kJ/mol), salt bridges (formed between oppositely charged residues, distance 5.5 , energy range in 313 kJ/mol), hydrophobic interactions (aggregation of hydrophobic groups), Stacking (weak interactions of aromatic rings between electron-rich and electron-deficient systems), -cation interactions (interactions between -systems (e.g., aromatic rings) and cations (e.g., positively charged residues))
Sartorelli & David G
The trial did have a conflict of interest in that it received support from a company that provides Setria, but it was also a randomized, double-blinded, and placebo-controlled trial with sound methods
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