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More studies are needed to verify whether the hepatoprotective effect of natural products through this novel mechanism

High-quality human clinical trials are lacking, and optimal dosing, long-term safety, and efficacy have not been established, meaning its use for IBS and Crohns should be considered investigational rather than a standard therapeutic option

New therapies, like a biomimetic -MSH peptide, may be effective for preventing and reversing gray hair, at least according to a limited number of clinical trials

Mild irritation may occur in sensitive individuals discontinue use if persistent redness or itching develops