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Nature, 2008, 454(7203):436-44

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In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway, 154 although GLP-1 receptor expression in VTA neurons is relatively sparse

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The potential mechanism of GLPs action in IBD may include promotion of tissue repair of injured epithelium, regulation of T cell differentiation and functions, regulation of innate immune cells such as macrophages and dendric cells, and reduction of proinflammatory cytokines (Fig

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