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Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work

It's also thought to help keep cholesterol levels in check

Typical shot schedules use a short loading phase (26 weeks) followed by monthly to every 23 months maintenance (AAFP

While receiving an IV drip that provides NAD+, you can also get an intramuscular shot of vitamin B12, or you could have the nutrients added to the IV bag