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First identified in human plasma in the 1970s, GHK-Cu levels decline with age, prompting research into its therapeutic applications

This does not invalidate the findings, but it means the evidence base is not yet at the level of FDA-approved pharmaceuticals

Interestingly, tirzepatide also markedly reduced body weight in patients with type 2 diabetes, which led to studies on its efficacy for the treatment of obesity in the absence of type 2 diabetes

Cleveland Clinic researchers presented a propensity-matched analysis of 10,225 patients who initiated GLP-1 receptor agonist therapy (semaglutide or tirzepatide