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The adjacent triphenolic group of GA can simultaneously form multiple hydrogen bonds and coordination bonds with metal ions, making it easier to be oxidized in the complex and generating stable dimer and polymeric products

10.1056/NEJMoa2504214 37 JensenS.BlondM

Most clinical trials of semaglutide focused on diabetes and obesity outcomes

The rationale is elegant: because GLP-1 receptors are enriched in metabolically active brain regions, using GLP-1 as a delivery vehicle allows estrogen to be directed preferentially toward the central nervous system, potentially enhancing its neuroprotective effects while limiting systemic hormonal exposure