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An ideal animal model not only exhibits the same symptoms and pathological changes as a human disease but also follows the same sequence of pathological events

Thus, researchers propose that growth hormone secretagogues like Ipamorelin might elevate fat levels through mechanisms that do not involve growth hormone directly, possibly by enhancing food intake

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Although AGE/RAGE-dependent ROS likely contributes substantially, this pathway alone is unlikely to explain the reproductive phenotype (reduced pregnancy rates, increased miscarriages, and smaller litters)