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Remarkably, among all detected metabolites, we observed the largest reductions in the levels of oxidized or reduced glutathione in mitochondria of SLC25A39 knockout cells (Fig

Inhibition of lipid peroxidation in PMN-MDSC in immunocompetent mice unexpectedly abrogated their suppressive activity and reduced tumor progression to synergize with immune checkpoint blockade to suppress tumor growth (112)

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