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The cuproptosis-related genes fdx1 and lias showed increased expression at low temperatures in B6J mouse cells, with levels about twice as high in cells from noncold-tolerant B6J mice compared with cold-tolerant STM2 mice (Supplementary Table S2)

Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial

Pickart and Margolinas 2018 review in Int J Mol Sci catalogs its regenerative and protective actions matrix remodeling, antioxidant and anti-inflammatory gene modulation, and wound-repair signaling but this is a review of largely preclinical and cell-based work (PMC6073405)

Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)