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The intrinsic pathway involves increased permeability of the mitochondrial outer membrane, releasing cytochrome c, which binds to Apaf-1 to form an apoptosome, activating caspase-9, and subsequently activating caspase-3, leading to programmed cell death

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DSIP has also been studied for antioxidant properties and neuroprotective potential in cell culture models, and for its interaction with opioid peptide systems and basal ganglia function

Su mecanismo de accin es notablemente amplio: modula la expresin de ms de 4,000 genes, estimula la sntesis de colgeno tipo I y III, y acta como un potente antioxidante en modelos experimentales