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Eight studies had low risk of bias (43, 5557, 61, 64, 71, 72), 11 studies had moderate risk of bias (44, 48, 50, 54, 58, 63, 65, 68, 74, 75, 79) and 22 studies had high risk of bias (4547, 49, 5153, 59, 60, 62, 66, 67, 69, 70, 73, 7678, 80)

Semaglutide is administered via weekly subcutaneous injections or daily sublingual tablets, and must be titrated up over several weeks under a provider's guidance to allow the body to adjust to the medication

Tirzepatide can make birth control pills less effective

35 One of the most attractive features of GLP-1 drugs is that they shut off the food noise so many people experience that makes staying in a caloric deficit or even just changing food preferences so difficult