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doi: 10.3389/fnut.2025.1686777 Received 15 August 2025 Revised 15 November 2025 Accepted 28 November 2025 Published 12 January 2026 Volume 12 - 2025 Edited by Andrea Orellana-Manzano, Escuela Superior Politcnica del Litoral (ESPOL), Ecuador Reviewed by Paulina Cerda Opazo, Autonomous University of Chile, Chile Aliakbar Fazaeli, Ardabil University of Medical Sciences, Iran Updates Copyright 2026 Garutti, de Scordilli, Alberti, Mazzeo, Michelotti, Fagioli, Del Conte, Casirati, Caccialanza, Bartolini and Puglisi

The most common effects are mild injection site reactions (temporary redness or slight discomfort), occasional mild water retention (often temporary and dose-dependent), rare reports of mild tingling or numbness in extremities (usually transient), mild increases in hunger in some subjects (less common than with GHRP-6), and occasional mild headaches (often resolve quickly)

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Consider which protocol you can realistically maintain long-term, as consistency determines outcomes with either compound