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In the Phase 2 obesity trial (Jastreboff et al., New England Journal of Medicine , 2023), investigators reported dose-dependent mean weight reduction of up to 17.5% at 24 weeks and up to 24.2% at 48 weeks

Chronic BDNF treatment has been comparatively less investigated, besides it may represent a therapeutic option to obtain rescue of post-injury alterations of synaptic networks

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