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Lu BC, Huang L, Cao J, Li LL, Wu WH, Chen XL, Ding C

The pro-apoptotic and anti-proliferative activities of eckol (a marine-derived phlorotannin) are demonstrated by the upregulation of Bax, caspase-3, and caspase-9 expression, alongside downregulation of Bcl-2 expression through in vivo experiments (Huang et al., 2020)

Nearly every cell in the body contains glutathione (GSH) 18 , and it is widely distributed in many vital organs and tissues

Therefore, more detailed studies will be needed to establish whether BAMs (e.g., GCDCA, DCA, GUDCA) influence the ferroptosis of joint tissue cells, such as chondrocytes and synoviocytes, along this axis, promoting the initiation and progression of OA