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These nano-sized vesicles are essential mediators of intercellular communication and play a pivotal role in tissue repair and regeneration, underscoring the therapeutic potential of MSCs in regenerative medicine [57]

However, in contrast to the tumour-suppressive effects described above, there is evidence that CDO1 can have a tumorigenic effect associated with aggressive glioblastoma, since its overexpression was detected in these tumours

No study has systematically measured the duration of benefit after treatment cessation or established optimal retreatment intervals

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