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The best characterized intracellular substrates for the insulin and IGF-I receptors are the insulin receptor substrate proteins 1 to 4[250]
Moreover, it is now well established that the reversible formation of mixed disulfide GSSR through protein- S -glutathionylation is an important on/off mechanism for dynamic post-translational regulation of a variety of regulatory, structural and metabolic proteins involved in signaling and metabolic pathway in cell systems (Ghezzi, 2005, 2013)
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