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Mechanistic analyses reveal that TMAO activates the NOX pathway to increase ROS production

2022;20:e538-47

Despite SNPs in genes functionally related to taste buds, also genetic variations in other genes have been shown to affect the taste perception and are likewise correlated with parameters of obesity

demonstrated that oxidative stress, mediated by ROS, plays a crucial role in depression induction, and Nrf2 activation can mitigate oxidative stress by simultaneously regulating multiple potential mechanisms, including autophagy and ferroptosis (ZUO et al., 2022)