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They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies

Example dosage schedule Starting dose: 0.2 0.3 mg weekly for first 4-5 weeks Titration phase: 0.4 0.6 mg weekly for 4-5 weeks and then, if tolerated, 0.9 1.1 mg weekly for 4-5 weeks Maintenance dose for long-term weight management: 1.6 1.9 mg weekly for 4-5 weeks and then, if tolerated, 2.5 mg weekly (maximum dose) The dosage may vary depending on the individual needs, your initial BMI, and glycemic control