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A study performed in primary cultures of OFs from GO patients and control subjects demonstrated that quercetin exerts an inhibitory effect on fibroblasts proliferation and HA release, with no difference between GO and control fibroblasts ( in vivo studies are needed to confirm this hypothesis, also considering that quercetin seems to act through necrosis, which may worsen autoimmunity against orbital antigens due to antigen exposure to the immune system

Two well-studied endocannabinoids are Anandamide (AEA), the bliss molecule, which is thought to affect mood, and 2-arachidonoylglycerol (2-AG), which plays an important role in the regulation of food intake and energy metabolism, anxiety and depression, addiction, immune system function, inflammation, and proliferation and invasion of certain types of cancer cells

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Peptides, 27(6), 14761482