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Glucagon receptor activation is thought to increase energy expenditure and promote fat breakdown (lipolysis), which may help explain the substantial weight loss observed in early-phase trials however, these mechanistic effects have not yet been fully characterised in humans and should be regarded as preliminary findings
86 In patients with T2D and high cardiovascular risk, semaglutide use has resulted in fewer serious cardiac and kidney disorders compared to placebo but is linked to worsening diabetic retinopathy, likely due to rapid glucose reduction
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