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The surge in cAMP activates protein kinase A (PKA), which in turn increases the expression of the transcription factor MITF, the master regulator of melanogenesis

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doi:10.1093/sleepadvances/zpaa002

In the SCALE Obesity and Prediabetes trial (Pi-Sunyer et al., NEJM 2015), participants receiving Saxenda alongside lifestyle modification achieved mean weight loss of approximately 8% of initial body weight, compared with 2.6% in the placebo group