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Peacock BN, Gherezghiher TB, Hilario JD, Kellermann GH

In addition, in the pathogenesis of GERD, the abnormalities of digestive tract dynamics have gradually been emphasized by researchers, and it has been further found that the brain-gut peptide (neurotransmitter) in the brain-gut axis is not only related to visceral hypersensitivity, but also plays an important role in regulating gastrointestinal dynamics, and changes in the bacterial microbiome and its structure can stimulate the secretion of brain-gut peptide, so the emphasis on the bacterial microbiome in the future research will also provide therapeutic opportunities for the treatment of GERD

These alterations impair nutrient absorption, reduce the bioavailability of amino acids including leucine, and contribute to chronic low-grade inflammation that exacerbates anabolic resistance and endothelial dysfunction

"The Nobel Prize in Physiology or Medicine 2020"