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First-line recommendations from the American Diabetes Association, American College of Physicians, and U.S

Second Generation The second generation moved from single GLP-1 activity toward dual incretin agonism

Discussion Here we report the development of a unimolecular quintuple agonist that combines the body weight and blood glucose-lowering effects of GLP-1GIP co-agonism with the insulin-sensitizing and anti-inflammatory properties of the nuclear-acting PPAR// triple agonist Lani through targeted delivery into cells expressing GLP-1R and/or GIPR

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