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Thyroid: Off J Am Thyroid Assoc (2017) 27(2):2718

This slowed absorption can reduce the effectiveness of oral contraceptives , increasing the risk of unintended pregnancies

FDAs reviewers note that direct evidence for that specific causal attribution is lacking : demonstrating that the half-life of CJC-1295 DAC is longer than that of CJC-1295 without the DAC modification is the experiment that would be needed, and it has not been published

Further investigations are underway to assess the full extent of the issue