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doi:10.1002/14651858.CD012357.pub2 42 Chen, C.-C

(2025), showed tirzepatide produced a 10.9% reduction in lean mass, though the lean-to-fat loss ratio was more favorable at roughly 25% lean and 75% fat

Because more free peptide reaches tissues, in vitro receptor-activation studies show that IGF-1 LR3 produces near-maximal IGF-1R phosphorylation at lower molar concentrations than the native ligand [2]

This timeline is intended for educational purposes and should not be interpreted as a guarantee that every patient will experience the same results