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Sometimes, a dark black spot on lip is flat, while in other cases it may be slightly raised
The percentage is a choice reasonable formulators could debate at the margins 0.10% versus some other figure in the studied range
Importantly, we also evaluate the landscape of candidate ferroptosis-related biomarkers, which are indispensable for clinical translation, and discuss the major challenges that must be addressed to advance ferroptosis-targeted interventions from preclinical models to patient care
The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases
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