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The percentage of participants achieving clinically meaningful thresholds (5%, 10%, 15%, 20%+ weight loss) exceeded anything previously seen with GLP-1 based therapies

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The pattern is that both are GI-forward drugs, but retatrutides glucagon activity adds a cardiovascular consideration (heart rate) that cagrilintides amylin mechanism does not, and the same potency that produces retatrutides larger weight loss is associated, in indirect analyses, with a heavier adverse-event load