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7.5 Serious Adverse Reactions and Red Flags Serious reactions, though uncommon, include: Pancreatitis Gallbladder disease Severe hypersensitivity reactions 8

At 52 weeks, orforglipron showed superior weight-loss maintenance vs placebo , with minimal regain in patients switching from semaglutide (regained 0.9 kg) and tirzepatide (regained 5.0 kg, which is still better than the placebo group)

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