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Interestingly, research on clonal pancreatic -cells revealed that fatty acid load stimulated GIPR expression via the activation of PPAR- transcriptional factor under normoglycemia (99 mg/dL), but not during hyperglycemia (450 mg/dL) (59)

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Meanwhile, the ECD rotates downward to fill the transmembrane domain (TMD) and accommodate GLP-1(9-36), evidenced by a 10.5 downward movement of the N-terminal -helix (measured at the C atom of S31)

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