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Right upper quadrant pain, especially if accompanied by fever or yellowing of the skin/eyes (jaundice), requires urgent evaluation as GLP-1 receptor agonists have been associated with gallbladder disease

Using laxatives only as needed can prevent this issue

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From a pathophysiological perspective, my first thought is that this could reflect an indirect effect on peripheral nerve sensitivity, possibly related to: rapid shifts in glucoselipid metabolism, changes in nerve conduction due to electrolyte fluctuations, or even a centrally mediated effect, considering GLP-1 receptor expression in the CNS