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In compensated cirrhosis, circulating melatonin levels have been reported to correlate with disease-related parameters (details relating to blood parameters affected by oxidative stress, inflammation, and liver problems such as malondialdehyde (MDA), C-reactive protein (CRP), TNF- (tumor necrosis factor-), ALT (alanine aminotransferase), AST (aspartate aminotransferase), and bilirubin are noted to be associated with levels of circulating melatonin), which suggest a compensation and potentially protective role as the disease progresses [98]