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This process begins with cystine deprivation, which typically induces ferroptosis by depleting intracellular GSH, a critical antioxidant

ES NDs effectively reduce the abnormal accumulation of Fe 2+ , GPX4 inactivation, and lipid peroxidation in chondrocytes, thereby improving the metabolic disorders of chondrocytes caused by ferroptosis, and show significant therapeutic effects in alleviating OA

Functional GTP cyclohydrolase 1 exists as a homodecamer that consists of two tightly associated dimers that each comprise a pentameric complex of the GTP cyclohydrolase 1 monomers

It also plays a crucial role in the functioning of the nervous system, as it is needed to produce the protective covering of nerves known as myelin