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Fluid balance : Creatine promotes intracellular water retention in muscle

FASEB J (2003) 17:196971

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Weight loss in patients with obesity but no HF is associated with effects that would be expected to reduce symptom severity and improve exercise function in patients with HFpEF, including reversal of hypertrophic chamber remodeling, improvement in ventricular mechanics and reductions in hemodynamic congestion 13,14