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For women of reproductive age with PCOS, the priority is to simultaneously strengthen fertility planning and contraceptive management while improving ovulatory opportunities, ensuring weight and metabolic stability during the preconception washout period to avoid the maternal-fetal risks associated with a weight lossrebound cycle (133, 137)

Those with severe liver or kidney disease (use with extreme caution or as advised by a doctor)

Table 4 Recommendations for policymakers and healthcare systems

Type 2 diabetes is the most common type, accounting for an estimated 90 to 95 percent of all diagnosed adult diabetes cases in the U.S