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In contrast, free proline and 4-hydroxyproline in the lumen are taken up into the cells primarily by the Na + -dependent system IMINO transporter and the system NBB transporter (present on the brush border for the transport of neutral amino acids), as well as the Na + -independent system L transporter (Brandsch 2006)

Gateway has conducted more than a dozen studies showing these ingredients possess multi-pathway metabolic effects, Kothari says

Due to the lack of precise data on the effectiveness and safety of this method, it should be approached carefully, and medical consultation is recommended before use

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