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53 In longer studies of 612 months ( n = 2887), combining 5002000 mg/day metformin with various COCPs led to greater reductions in FAI, free testosterone, and inflammatory markers, and improvements in body composition, facial hirsutism, vascular function, and aortic elasticity than either treatment alone, although no additional benefits were seen for lipids, insulin sensitivity, SHBG, or testosterone beyond those provided by COCPs alone

Providers monitor patient response and recommend gradual dose increases to support better tolerance and steady progress

Patients with existing kidney disease should seek medical advice earlier as they are at higher risk of acute kidney injury from dehydration

If you are unsure about past reactions, review your medical records with your doctor