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To ensure methodological clarity, avoid overstating analytical rigor and to address the inherent heterogeneity of comparing controlled clinical trials with observational real-world evidence, no original quantitative meta-analysis or formal risk-of-bias assessments were conducted

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Interestingly, despite its earlier discovery in 1844 by the Italian chemist, Michele Peyrone, CP did not attract much attention until 1965 (Dasari and Bernard Tchounwou, 2014)