The researchers behind it come from leading research centres, and the fact that it has been peer-reviewed and published in a reputable journal indicates that it is a serious piece of work
Ototoxicity risk factors include the cumulative dose, impaired renal function, route of administration, cranial irradiation, previous sensorineural hearing loss, age under five years, concomitant use of ototoxic drugs, genetic susceptibility, and tumor localization (16)
This is where semaglutide may have a big advantage right now because it has been around for years, is already FDA approved for both diabetes and weight loss, and researchers have had the time to gather large amounts of real-world data on millions of patients
Data Animal Data Embryo-fetal development was evaluated in female rats administered setmelanotide subcutaneously during mating to end of major organogenesis (14 days prior to mating to gestation day 17) at doses of 0.5, 3, and 5 mg/kg/day, resulting in exposures up to 11 times the human exposure at MRHD of 3 mg, based on AUC