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Protein (milk- or plant-based) and minerals (Zn/Se) are categorized as having moderate evidence, indicating potential but necessitating further targeted RCTfor instance, the efficacy of protein depends on bioavailability and an intake threshold of 1.2 g/kg body weight/day (27, 28), while zinc dosage should be maintained at 1520 mg/day (252, 279) to avoid microbiota disruption

Ibuprofen Given for 4 weeks, ibuprofen severely disturbed both lower esophageal sphincter and pyloric sphincter

They should start with smaller doses