Elevated circulating insulin levels and IR provide an unfavorable biochemical environment in the ovaries, increasing both androgen over-synthesis and lipid metabolism from theca cells, that in turn induce a central distribution of fat and dyslipidemia
Patients should be educated about signs and symptoms of potential serious adverse effects, including pancreatitis, gallbladder disease, and severe hypoglycemia if receiving concurrent antidiabetic therapy
One patient was reported to have learning disability with dyslexia and was also thought to be mentally retarded [5], and another had delayed psychomotor development and progressive sensory neuropathy of lower extremities, ataxia, hyperreflexia, dysarthria, and a peculiar gait suggestive of spinocerebellar degeneration [2]
Resveratrol has garnered considerable global interest due to its capacity to prevent or slow the progression of numerous animal diseases, including cardiovascular diseases and cancer (Crozier, Jaganath and Clifford 2009)
