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Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance

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GLP-1 for sleep apnea, alcohol use and cancer risk GLP-1s may address conditions well beyond metabolic diseases: Obstructive sleep apnea: Emerging data suggest GLP-1s improve apnea symptoms. Alcohol use disorder: Patients using liraglutide or semaglutide reduced alcohol consumption by nearly two-thirds. Obesity-related cancers: An observational study of 6,000 adults found that GLP-1 receptor agonists halved the risk of obesity-related cancers compared with usual care

In 3-AR knockout mice, however, no effect was observed with AOD9604 confirming the dependency of its chronic lipolytic action on 3-AR expression, while also suggesting an additional acute mechanism that may operate through a separate pathway