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SmTGR H571A pH titration To understand the influence proton concentration has on the rate of formation of the broad charge transfer, which has previously been assigned to the proximity of the C159 thiolate and FAD isoalloxazine ( 3 PO 4 to various pHs and the reaction was monitored at 540 nm

Future research should leverage advanced techniques like spatial multi-omics analysis and patient-derived organoids/assembloids to directly validate how iron accumulation drives senescence and fibrosis in this disease, which is crucial for translating this hypothesis into clinical practice