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For instance, a pathogenic process identified by scRNA-seq and localized to specific tissue niches (e.g., fibrotic regions or perivascular areas) through spatial transcriptomics can be tracked non-invasively by measuring corresponding protein or metabolite signatures in serum or urine, bridging mechanistic insight with clinical application

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These studies provide preliminary clinical signals, but they are primarily focused on assisted reproduction outcomes and do not isolate the independent contribution of each component