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Zhou [12] demonstrated that oxidative stress in pregnancy can increase, even if the exact either pro-oxidant or antioxidant status in pregnancy-induced hypertensive patients is not clear [13]

For de novo NADPH synthesis pathway, correlation studies have revealed that thionicotinamide adenine dinucleotide (NADS) and thionicotinamide adenine dinucleotide phosphate (NADPS), converted from the pro-drug thionicotinamide (TN), act as inhibitors of NADKs through targeting the NAD-binding site of NADKs and decreasing the levels of NADPH

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It is recommended to store the vial in a temperature-controlled environment between 2C and 8C