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Eur J Clin Investig 45:12341242

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The safety of skin whitening treatments depends on the chosen dermatologist's expertise and experience, the suitability of an individual seeking the treatment, and compliance with treatment guidelines

Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease