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This research was supported by grants from the National Natural Science Foundation of China (32388101 and 32250001 to D.X., 32425011 and 32488302 to J.Y.), National Key R&D Program of China (2022YFD1400800 and 2021YFA1300400 to D.X.), China Postdoctoral Science Foundation (2020M670286 to Y.Y.), Postdoctoral Fellowship of Tsinghua-Peking Joint Center for Life Sciences

Most do not notice anything dramatic until the end of week one or the beginning of week two

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A t(2:22)(q34;q12) translocation resulting from the fusion of the EWSR1 and CREB1 genes has been reported in CCS that arises in the gastrointestinal tract.18 Notably, CCS is marked by the absence of mutations in BRAF that are commonly noted in malignant melanoma