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to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease

In a small pilot study of patients with metabolic syndrome, those who received high-dose intravenous L-carnitine (4 g/day) during a medically supervised fasting period reported less hunger than those in the placebo group

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Despite these favourable data, drop-out rates of 41-68% have been reported for intracavernous pharmacotherapy [434,462,466,467], with most discontinuations occurring within the first two to three months