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Researchers using IGF-1 LR3 in muscle wasting studies at doses of 60mcg daily observed significant increases in lean mass only when combined with resistance training and protein intake above 1.6g/kg/day

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Increased body fat in the upper chest and obliques Abdominal weight gain Lethargy/fatigue Brain fog Mood swings Irritability Low libido Depression Anxiety Long term, excess estrogen in men can trigger abnormal cell growth and prostate enlargement

The cellular uptake of nanoparticles involves various endocytic pathways, including phagocytosis, macropinocytosis, clathrin- and caveolin-mediated endocytosis