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adverse or undesired effects Examples -- positive, beneficial drug interaction effects: Propranolol + hydralazine (reflex tachycardia (undesirable) caused by hypotensive hydralazine-mediated response is prevented by propranolol-mediated -adrenergic receptor blockade Opioid-induced respiratory depression may be counteracted by administration of the opioid receptor antagonist naloxone Adverse effects -- toxic reactions One drug may interact with another to impede absorption One drug may compete with another for the same plasma protein-binding sites One drug may affect metabolism of another by either enzyme induction or enzyme inhibition One drug may change the renal excretion rate of the other

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Notably, serine was significantly reduced both in vivo and in vitro , suggesting it is being used as a substrate by UPEC

GLP-1 receptor agonists are well suited for early use in type 2 diabetes because they stimulate release of insulin and suppress glucagon secretion only when blood glucose concentrations are elevated